Luctor et Emergo
Thursday, February 21, 2008
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CFIDS,
M.E,
NO/ONOO cycle,
Pall protocol
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0
comments
'I Struggle and Emerge' -- it's my blog title. If you have read the first post below you will know that I'm struggling and I keep on struggling but I _do_ hope to emerge someday. I was tempted to delete the posting and start fresh but just decided to leave it, maybe someone will recognize the feelings and it will let them know they're not alone in this.
Well something had to give, I couldn't continue to carry on like this any longer. I picked up a book written by a Biochemist Scientist, dr.Martin Pall - 'Explaining 'Unexplained Illnesses'.
It was a difficult read, dr. Pall is a Bio-Chemicus and not a medical dr. so he looks at illness at cell level and not as medical dr's do at blood level. Luckily I have my own scientist at home, although not a bio-chemist W. knows how to read scientific material even if he's not familiar with the content. So he read the difficult parts for me and explained what I couldn't grasp through my brain-fog.
In the book dr.Pall describes his research and his theory which he calls the 'NO/ONOO- cycle' To explain his theory in short:
dr. Pall believes all 'Unexplained Illnesses" ( Fibromyalgia, CFS, Multiple Chemical Sensitivity, Post Traumatic Stress Syndrom, Gulf War Syndrome etc.) are Initiated by Short Term Stressors.
For Chronic fatigue syndrome/Myalgic Encephalomyelitis this can be:
Viral infections, bacterial infections, physical trauma, severe psychological stress, carbon monoxide exposure, organophosphorus pesticide exposure, ciguatoxin exposure, toxoplasmosis (protozoan) infection.
He believes that these short-term stressors initiate a single complex biochemical cycle which elevates levels of potent oxidants in the body - the nitric oxide/peroxynitrite cycle (NO/ONOO- cycle) - and is responsible for causing CFS, FM, MCS, PTSD, and other chronic diseases.
He believes that this cycle need to be down regulated in order to be able to recover or improve.
Dr.Pall, a CFS patient himself, worked 8 years on this research. Together with dr. Grace Ziem, MD, specialist in MCS(Multiple Chemical Sensitivity), he developed a protocol that seems to help a lot of patients.
I was anxious after reading all the materials to start the protocol as well, until now nothing else seems to help, no pharmaceutical medications helped me get well, only treated one symptom until the next one appeared.
To me it all made sense.
I discussed the theory with my PCP and got tested before we started the protocol so we can keep track of various levels of deficiency and if would need something else besides what the protocol prescribes.
Ordering the compounded materials did take some time, we had to work out some kinks. Kudos go to my partner in crime W. who did all the calculations and explanations to our PCP. More kudos also to my PCP dr.Miller who was so open minded to work with me on this even though he was not familiar with the material and protocol. He didn't hesitate though to give his full support.
I received all medications, supplements and hardware ;-) to start going and thought it would be a good plan to document my process in this blog as I go along. Maybe it will help someone and it's good for me to keep track, vent my frustration, whine and celebrate every victory as I'm determined to EMERGE one day!
Will go into more details about the protocol over the next days, don't want to overwhelm you all ;-)
Well something had to give, I couldn't continue to carry on like this any longer. I picked up a book written by a Biochemist Scientist, dr.Martin Pall - 'Explaining 'Unexplained Illnesses'.
It was a difficult read, dr. Pall is a Bio-Chemicus and not a medical dr. so he looks at illness at cell level and not as medical dr's do at blood level. Luckily I have my own scientist at home, although not a bio-chemist W. knows how to read scientific material even if he's not familiar with the content. So he read the difficult parts for me and explained what I couldn't grasp through my brain-fog.
In the book dr.Pall describes his research and his theory which he calls the 'NO/ONOO- cycle' To explain his theory in short:
dr. Pall believes all 'Unexplained Illnesses" ( Fibromyalgia, CFS, Multiple Chemical Sensitivity, Post Traumatic Stress Syndrom, Gulf War Syndrome etc.) are Initiated by Short Term Stressors.
For Chronic fatigue syndrome/Myalgic Encephalomyelitis this can be:
Viral infections, bacterial infections, physical trauma, severe psychological stress, carbon monoxide exposure, organophosphorus pesticide exposure, ciguatoxin exposure, toxoplasmosis (protozoan) infection.
He believes that these short-term stressors initiate a single complex biochemical cycle which elevates levels of potent oxidants in the body - the nitric oxide/peroxynitrite cycle (NO/ONOO- cycle) - and is responsible for causing CFS, FM, MCS, PTSD, and other chronic diseases.
He believes that this cycle need to be down regulated in order to be able to recover or improve.
Dr.Pall, a CFS patient himself, worked 8 years on this research. Together with dr. Grace Ziem, MD, specialist in MCS(Multiple Chemical Sensitivity), he developed a protocol that seems to help a lot of patients.
I was anxious after reading all the materials to start the protocol as well, until now nothing else seems to help, no pharmaceutical medications helped me get well, only treated one symptom until the next one appeared.
To me it all made sense.
I discussed the theory with my PCP and got tested before we started the protocol so we can keep track of various levels of deficiency and if would need something else besides what the protocol prescribes.
Ordering the compounded materials did take some time, we had to work out some kinks. Kudos go to my partner in crime W. who did all the calculations and explanations to our PCP. More kudos also to my PCP dr.Miller who was so open minded to work with me on this even though he was not familiar with the material and protocol. He didn't hesitate though to give his full support.
I received all medications, supplements and hardware ;-) to start going and thought it would be a good plan to document my process in this blog as I go along. Maybe it will help someone and it's good for me to keep track, vent my frustration, whine and celebrate every victory as I'm determined to EMERGE one day!
Will go into more details about the protocol over the next days, don't want to overwhelm you all ;-)
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