Just received an email from dr. V(finally, a reply to my email of 3 weeks ago!) that he received more test results from the 21 vials stuff.
The test is C4A level, a specific immune component and it is very high at 34,815 (Normal range is 0-2830).
So it shows my immune system is very active and this contributes to your symptoms.
I understand that part but WHY is my immune system so active? Is it because of the high Viral and Bacterial load?
What worries me is that dr.V says that it does not require immediate action. I wonder where he bases that on. Those figures to me look extremely high. I had nothing to compare my levels with, most studies have been done for Lyme disease and that doesn't generate such high levels.
I came across a poster session that has been done by dr.Shoemaker where he treats CFS patients with high amount of C4A with low doses of a drug called EPO or erythropoietin.
A poster session at a clinical meeting is for attendees who have information they want to share but whose data either were not submitted at all or else may not have been accepted as a clinical paper for presentation. You gather your data and put it on a large sheet of poster board and then exhibit it for a set period of time while other attendees mill around, hopefully reading your poster, all the while you stand there ready to answer questions.
<quote>
Erythropoietin (EPO) its function is a blood volume enhancer, is apparently also very effective at reducing C4a levels in inflammatory diseases. This lead to Dr. Shoemaker giving 60 CFS patients 8000 units of EPO five times over 15 days and then measuring their C4a and symptom levels.
The results had an interesting dichotomy; while the C4a levels in all the patients dropped, about 80% of the patients symptomatically improved while 20% did not. It turns out that the 20% who did not improve had exceptionally high C4a levels. Normal C4a levels are below 2830 ng/ml.
The responders dropped their C4a levels from 8300 to near normal, about 3200 ng/ml.
The non-responders initial levels were so high, about 19,500 ng/ml that even substantial improvement still left them with higher levels than the responders had at baseline (12,500 ng/ml). In short, it appeared that their C4a levels were too high for the EPO to give them relief at the dosage given.
<end quote>
So their levels about 19,500 are considered extremely high, compare my levels of 34,815 they must be enormous than.
What I did read, according to wiki is that C4a is a human gene part of the Complement component 4A. The Complement system is part of the larger immune system that is not adaptable and does not change over the course of an individual's lifetime; as such it belongs to the innate immune system. However, it can be recruited and brought into action by the adaptive immune system.
C4a is a Anaphylatoxin. Anaphylatoxin is able to trigger degranulation of (release of substances from) mast cells or basophils, which is an important part of the immune system in all kinds of inflammation and especially as part of defense against parasites. If the degranulation is too strong, it can cause allergic reactions.
I guess you can say that in my case degranulation is too strong.
Anyway, my body is so much depleted at the moment we need to get it into shape first before I can start treatment for the viral stuff.
For once, for one g*ddammned time I wished I got some medication of whatever that would make me feel a tiny tiny bit better. Just a small lift in my pain or exhaustion would be nice.
I’m sorry to say that I’m really really am getting depressed about it all and have a very negative feelings while I should think happy positive thoughts to encourage my healing.
I’ve got nothing left to pull it from.
# # #
The test is C4A level, a specific immune component and it is very high at 34,815 (Normal range is 0-2830).
So it shows my immune system is very active and this contributes to your symptoms.
I understand that part but WHY is my immune system so active? Is it because of the high Viral and Bacterial load?
What worries me is that dr.V says that it does not require immediate action. I wonder where he bases that on. Those figures to me look extremely high. I had nothing to compare my levels with, most studies have been done for Lyme disease and that doesn't generate such high levels.
I came across a poster session that has been done by dr.Shoemaker where he treats CFS patients with high amount of C4A with low doses of a drug called EPO or erythropoietin.
A poster session at a clinical meeting is for attendees who have information they want to share but whose data either were not submitted at all or else may not have been accepted as a clinical paper for presentation. You gather your data and put it on a large sheet of poster board and then exhibit it for a set period of time while other attendees mill around, hopefully reading your poster, all the while you stand there ready to answer questions.
<quote>
Erythropoietin (EPO) its function is a blood volume enhancer, is apparently also very effective at reducing C4a levels in inflammatory diseases. This lead to Dr. Shoemaker giving 60 CFS patients 8000 units of EPO five times over 15 days and then measuring their C4a and symptom levels.
The results had an interesting dichotomy; while the C4a levels in all the patients dropped, about 80% of the patients symptomatically improved while 20% did not. It turns out that the 20% who did not improve had exceptionally high C4a levels. Normal C4a levels are below 2830 ng/ml.
The responders dropped their C4a levels from 8300 to near normal, about 3200 ng/ml.
The non-responders initial levels were so high, about 19,500 ng/ml that even substantial improvement still left them with higher levels than the responders had at baseline (12,500 ng/ml). In short, it appeared that their C4a levels were too high for the EPO to give them relief at the dosage given.
<end quote>
So their levels about 19,500 are considered extremely high, compare my levels of 34,815 they must be enormous than.
What I did read, according to wiki is that C4a is a human gene part of the Complement component 4A. The Complement system is part of the larger immune system that is not adaptable and does not change over the course of an individual's lifetime; as such it belongs to the innate immune system. However, it can be recruited and brought into action by the adaptive immune system.
C4a is a Anaphylatoxin. Anaphylatoxin is able to trigger degranulation of (release of substances from) mast cells or basophils, which is an important part of the immune system in all kinds of inflammation and especially as part of defense against parasites. If the degranulation is too strong, it can cause allergic reactions.
I guess you can say that in my case degranulation is too strong.
Anyway, my body is so much depleted at the moment we need to get it into shape first before I can start treatment for the viral stuff.
For once, for one g*ddammned time I wished I got some medication of whatever that would make me feel a tiny tiny bit better. Just a small lift in my pain or exhaustion would be nice.
I’m sorry to say that I’m really really am getting depressed about it all and have a very negative feelings while I should think happy positive thoughts to encourage my healing.
I’ve got nothing left to pull it from.
# # #
(0) Comments